ENDS Adults Who Smoke: Difference between revisions
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Richardpruen (talk | contribs) (→Suggested studies to add to this page: added study re inequalities) |
Richardpruen (talk | contribs) (→Race / Ethnic / Socioeconomic / Education: added genetic variation study and added genetic to title) |
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=Race / Ethnic / Socioeconomic / Education= | =Race / Ethnic / Socioeconomic / Education / Genetic= | ||
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*Acknowledgement: The review is part of a project funded by Cancer Research UK. The award number is: C55561/A21553. | *Acknowledgement: The review is part of a project funded by Cancer Research UK. The award number is: C55561/A21553. | ||
=== 2019: [https://bpspubs.onlinelibrary.wiley.com/doi/10.1002/prp2.468 Nicotine oxidation by genetic variants of CYP2B6 and in human brain microsomes] === | |||
* Tobacco consumption and liability to nicotine dependence are heritable traits. One clearly implicated pathway is the C-oxidation of nicotine to nicotine iminium ion and subsequently to cotinine by CYP2A6, one of three nicotine metabolism pathways. | |||
* Common variation in the ''CYP2B6'' gene, encoding the cytochrome P450 2B6 enzyme, is associated with substrate-specific altered clearance of multiple drugs. CYP2B6 is a minor contributor to hepatic nicotine metabolism, but the enzyme has been proposed as relevant to nicotine-related behaviors because of reported ''CYP2B6'' mRNA expression in human brain tissue. | |||
* Human cell study | |||
* Adam Joseph Bloom, Pan-Fen Wang, Evan D. Kharasch First published: 11 March 2019 | |||
* This work was supported by the National Institutes of Health grants K01DA034035, R01DA14211 and R01DA25931. | |||
===2019: [https://academic.oup.com/ntr/article/21/10/1363/5039191?login=true Socioeconomic Disparities in Electronic Cigarette Use and Transitions from Smoking]=== | ===2019: [https://academic.oup.com/ntr/article/21/10/1363/5039191?login=true Socioeconomic Disparities in Electronic Cigarette Use and Transitions from Smoking]=== | ||