Nicotine therapeutic benefits: Difference between revisions
Richardpruen (talk | contribs) Added stroke heading and animal study on the protective effect of nic |
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*Acknowledgements: This work was supported in part by the Philip Morris External Research Program and the Kentucky Science and Engineering Foundation. | *Acknowledgements: This work was supported in part by the Philip Morris External Research Program and the Kentucky Science and Engineering Foundation. | ||
*Key words: spinal cord injury; nicotine; neuronal nicotinic receptors; oxidative stress; inflammatory responses; nitric oxide synthase | *Key words: spinal cord injury; nicotine; neuronal nicotinic receptors; oxidative stress; inflammatory responses; nitric oxide synthase | ||
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= Stroke = | |||
=== 2025: '''[https://academic.oup.com/ntr/advance-article-abstract/doi/10.1093/ntr/ntaf034/8005730?redirectedFrom=fulltext&login=false The protective effect of low-dose nicotine on ischemia stroke by maintaining the integrity of the blood-brain barrier]''' === | |||
* Animal study (mice) | |||
* These results demonstrate that nicotine treatment could alleviates the IS-compromised integrity of BBB by regulating the Wnt signal pathway through α7 nAChR. | |||
* The study demonstrates that nicotine at low concentrations exerts neuro-protective effects by supporting the integrity of BBB and subsequent endothelial viability after ischemic stroke. | |||
* Qianqian Pang, Xinyang Yan, Zheng Chen, Liang Yun, Jiang Qian, Zeyi Dong, Miao Wang, Wei Deng, Yao Fu, Tao Hai, Zhichao Chen, Xianfang Rong: Nicotine & Tobacco Research, ntaf034, <nowiki>https://doi.org/10.1093/ntr/ntaf034</nowiki> | |||
='''Tourette's Syndrome'''= | ='''Tourette's Syndrome'''= | ||