ENDS Toxicity / Carcinogenic: Difference between revisions
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Richardpruen (talk | contribs) (→ENDS (without comparison to other products): add study on protonating acid and if this affects anything (apparently not)) |
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=ENDS (without comparison to other products)= <!--T:61--> | =ENDS (without comparison to other products)= <!--T:61--> | ||
=== 2023: [https://pubmed.ncbi.nlm.nih.gov/37386281/ Assessing the impact of protonating acid combinations in e-cigarette liquids: a randomised, crossover study on nicotine pharmacokinetics] === | |||
* Frosina J, McEwan M, Ebajemito J, Thissen J, Taluskie K, Baxter-Wright S, Hardie G. Sci Rep. 2023 Jun 29;13(1):10563. doi: 10.1038/s41598-023-37539-6. PMID: 37386281 | |||
* Study in Humans | |||
* Funding from industry | |||
* BAT asks: does the protonating acid matter? | |||
** ''little is known about the impact of different combinations of protonating acid on nicotine pharmacokinetics.'' | |||
* So this is an experiment with "different ratios of three common protonating acids-lactic, benzoic and levulinic". | |||
** For most comparisons, Cmax and AUC0-60 following both fixed and ad libitum puffing were significantly higher for e-liquids containing 5% nicotine compared with 3.5% nicotine. However, Cmax and AUC0-60 were not statistically different for 5% nicotine e-liquids containing varying ratios of lactic, levulinic and benzoic acid when compared to an e-liquid containing lactic acid only. Mean scores for product liking were similar for all e-liquid formulations assessed, regardless of nicotine concentration, acid content, and whether the product was used in a fixed or ad libitum puffing regimen. | |||
** While e-liquid nicotine concentration significantly affected users' nicotine uptake, the different combinations of benzoic, levulinic and lactic acid in the e-liquids assessed had limited impact on nicotine pharmacokinetics and product liking scores.<br /> | |||
===2018 [https://www.tandfonline.com/doi/abs/10.1080/08958378.2018.1523262?fbclid=IwAR0x50Ru0cjsq_ojjcc2Qgdd7LUCqdmBnMqklhOLZ4sVFtoRNN-uOLSYiPM&journalCode=iiht20 Metal emissions from e-cigarettes: a risk assessment analysis of a recently-published study]=== <!--T:62--> | ===2018 [https://www.tandfonline.com/doi/abs/10.1080/08958378.2018.1523262?fbclid=IwAR0x50Ru0cjsq_ojjcc2Qgdd7LUCqdmBnMqklhOLZ4sVFtoRNN-uOLSYiPM&journalCode=iiht20 Metal emissions from e-cigarettes: a risk assessment analysis of a recently-published study]=== <!--T:62--> | ||