|
|
Line 341: |
Line 341: |
| =ENDS (without comparison to other products)= <!--T:61--> | | =ENDS (without comparison to other products)= <!--T:61--> |
|
| |
|
| | === 2023: [https://pubmed.ncbi.nlm.nih.gov/37386281/ Assessing the impact of protonating acid combinations in e-cigarette liquids: a randomised, crossover study on nicotine pharmacokinetics] === |
|
| |
|
| | * Frosina J, McEwan M, Ebajemito J, Thissen J, Taluskie K, Baxter-Wright S, Hardie G. Sci Rep. 2023 Jun 29;13(1):10563. doi: 10.1038/s41598-023-37539-6. PMID: 37386281 |
| | * Study in Humans |
| | * Funding from industry |
| | * BAT asks: does the protonating acid matter? |
| | ** ''little is known about the impact of different combinations of protonating acid on nicotine pharmacokinetics.'' |
| | * So this is an experiment with "different ratios of three common protonating acids-lactic, benzoic and levulinic". |
| | ** For most comparisons, Cmax and AUC0-60 following both fixed and ad libitum puffing were significantly higher for e-liquids containing 5% nicotine compared with 3.5% nicotine. However, Cmax and AUC0-60 were not statistically different for 5% nicotine e-liquids containing varying ratios of lactic, levulinic and benzoic acid when compared to an e-liquid containing lactic acid only. Mean scores for product liking were similar for all e-liquid formulations assessed, regardless of nicotine concentration, acid content, and whether the product was used in a fixed or ad libitum puffing regimen. |
| | ** While e-liquid nicotine concentration significantly affected users' nicotine uptake, the different combinations of benzoic, levulinic and lactic acid in the e-liquids assessed had limited impact on nicotine pharmacokinetics and product liking scores.<br /> |
|
| |
|
| ===2018 [https://www.tandfonline.com/doi/abs/10.1080/08958378.2018.1523262?fbclid=IwAR0x50Ru0cjsq_ojjcc2Qgdd7LUCqdmBnMqklhOLZ4sVFtoRNN-uOLSYiPM&journalCode=iiht20 Metal emissions from e-cigarettes: a risk assessment analysis of a recently-published study]=== <!--T:62--> | | ===2018 [https://www.tandfonline.com/doi/abs/10.1080/08958378.2018.1523262?fbclid=IwAR0x50Ru0cjsq_ojjcc2Qgdd7LUCqdmBnMqklhOLZ4sVFtoRNN-uOLSYiPM&journalCode=iiht20 Metal emissions from e-cigarettes: a risk assessment analysis of a recently-published study]=== <!--T:62--> |