VLN Cigarette

Safer nicotine wiki Tobacco Harm Reduction
Revision as of 17:23, 29 December 2020 by Richardpruen (talk | contribs)
Jump to navigation Jump to search

VLNCs

it has been suggested these pose all the risk, while offering none of the benefits

Studies

Very-Low Nicotine Cigarettes and Non-Daily Smokers https://clinicaltrials.gov/ct2/show/NCT02228824

Effects of 6-Week Use of Very Low Nicotine Content Cigarettes in Smokers With Serious Mental Illness

  • "These results suggest that a reduced-nicotine standard for cigarettes would reduce smoking among smokers with SMI. However, the lack of effect on total nicotine exposure indicates VLNC noncompliance, suggesting that smokers with SMI may respond to a reduced-nicotine standard by substituting alternative forms of nicotine."

https://www.sciencedirect.com/science/article/abs/pii/S0091743520302516

https://jamanetwork.com/journals/jama/article-abstract/2698925

  • " In this randomized clinical trial of 1250 smokers, immediate compared with gradual reduction to very low nicotine content cigarettes or with a control smoking group significantly reduced exposure (area under the concentration curve) to breath carbon monoxide (difference, 4.06 ppm and 3.38 ppm for immediate vs gradual reduction group and immediate reduction vs control group, respectively), acrolein (difference, 17% and 19%), and phenanthrene tetraol (difference, 12% and 14%); there were no significant differences between the gradual and control groups."


https://www.researchgate.net/publication/315653995_Estimating_Demand_and_Cross-Price_Elasticity_for_Very_Low_Nicotine_Content_VLNC_Cigarettes_Using_a_Simulated_Demand_Task


  • "Very Low Nicotine Content (VLNC) cigarettes might be useful as part of a tobacco control strategy, but relatively little is known about their acceptability as substitutes for regular cigarettes."

https://pubmed.ncbi.nlm.nih.gov/20078491/

  • "Unlike the 0.3 mg cigarettes, 0.05 mg cigarettes were not associated with compensatory smoking behaviors. Furthermore, the 0.05 mg cigarettes and nicotine lozenge were associated with reduced carcinogen exposure, nicotine dependence and product withdrawal scores. The 0.05 mg cigarette was associated with greater relief of withdrawal from usual brand cigarettes than the nicotine lozenge. The 0.05 mg cigarette led to a significantly higher rate of cessation than the 0.3 mg cigarette and a similar rate as nicotine lozenge."
  • It appears that VLNCs work best given with nicotine lozenges, therefore why not just try nicotine lozenges, and cut out the burning plant materials?


Discussion links BLOGs etc

Feds-should-think-twice-before-trying-to-reduce-nicotine-in-cigarettes